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Melanotan II is a synthetic peptide modeled on alpha-melanocyte-stimulating hormone (alpha-MSH), a natural hormone that signals skin cells to make melanin. Unlike alpha-MSH, melanotan II has a ring-shaped (cyclic) structure, and it acts on several melanocortin receptors rather than just one.
It was developed by researchers at the University of Arizona in the 1980s, in the same program that produced melanotan I.
Two FDA-approved medicines are related to melanotan II, but they are different drugs. Afamelanotide (melanotan I) is approved as Scenesse for a rare light-sensitivity disorder. Bremelanotide, which was derived from melanotan II, is approved as Vyleesi for a specific sexual desire condition in premenopausal women. Neither approval covers melanotan II.
Current status: Not FDA-approved.
Melanotan II is not the active ingredient in any FDA-approved medicine, and the FDA has not found it safe and effective for any use in people.
The FDA has issued warnings about melanotan products marketed online, and regulators in other countries have issued similar warnings. Products sold under this name are not approved drugs, so their contents, purity and safety have not been reviewed by the FDA.
Anyone concerned about changes in moles or skin pigment should see a dermatologist.
Peptide Labs does not sell this compound. This page is general information, not medical advice. We do not supply, prepare or distribute melanotan II in any form, and nothing on this page should be read as an offer.
If you have questions about melanotan II or a related health concern, talk to a licensed healthcare provider who knows your medical history.
See the full list of compound profiles in the Peptide Guide.
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